IMMUNE-ASSOCIATED GENE SIGNATURES SERVE AS A PROMISING BIOMARKER OF IMMUNOTHERAPEUTIC PROGNOSIS FOR RENAL CLEAR CELL CARCINOMA

Immune-Associated Gene Signatures Serve as a Promising Biomarker of Immunotherapeutic Prognosis for Renal Clear Cell Carcinoma

As the most common type of renal cell carcinoma (RCC), the renal clear cell carcinoma (ccRCC) is highly malignant and insensitive to chemotherapy or radiotherapy.Although systemic immunotherapies have been successfully applied to ccRCC in recent years, screening for patients who can benefit most from these therapies is still essential and challengi

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Obturator Manufacturing for Oronasal Fistula after Cleft Palate Repair: A Review from Handicraft to the Application of Digital Techniques

An oronasal fistula (ONF) is an abnormal structure between the oral and nasal cavities, which is a common complication of cleft palate repair due to the failure of wound healing.When some patients with ONF are unsuitable for secondary surgical repair, the obturator treatment becomes a potential method.The objectives of the obturator treatment shoul

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Further characterization of adult sheep ovarian stem cells and their involvement in neo-oogenesis and follicle assembly

Abstract Background Stem cells in the ovary comprise of two distinct populations including very small embryonic-like stem cells (VSELs) and slightly bigger progenitors termed ovarian stem cells (OSCs).They are lodged in ovary surface epithelium (OSE) and are expected to undergo neo-oogenesis and primordial follicle (PF) assembly in adult ovaries.Th

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